Platelet function defects related to cardiopulmonary bypass [letter; comment]

Platelet function defects related to cardiopulmonary bypass.

The platelet function defect of cardiopulmonary bypass.

The use of cardiopulmonary bypass (CPB) during cardiac surgery is associated with a hemostatic defect, the hallmark of which is a markedly prolonged bleeding time. However, the nature of the putative platelet function defect is controversial. In this study, blood was analyzed at 10 time points before, during, and after CPB. We used a whole-blood flow cytometric assay to study platelet surface g...

CONTINUING EDUCATION Coagulation and Platelet Function During Cardiopulmonary Bypass Surgery

Bachmann and coworkers in Chicago have performed a careful study of coagulation parameters after cardiopulmonary bypass surgery .1 In 512 patients, they found a 4% incidence of postoperative bleeding. More than half of these cases were due to surgically correctable causes. About 2% of the population were considered to be bleeding because of an acquired coagulation disorder. One half of these ca...

Rapid recovery of platelet function after cardiopulmonary bypass.

The complex mechanism of altered platelet function during cardiopulmonary bypass (CPB) is a subject under investigation because it might result in understanding of blood-biomaterial interaction and, subsequently, optimal intervention. However, the common biochemical and functional parameters of platelets do not clarify the mechanism.’ Recently, new apparatuses were constructed to mimic the hemo...

A rapid platelet function assay used to regulate platelet transfusion prophylaxis following cardiopulmonary bypass surgery.

Subsequent to cardiac surgery with cardiopulmonary bypass (CPB), patients are at risk of postoperative bleeding caused by acquired defects associated with the procedure. As such, many patients receive prophylactic blood product transfusion. The effectiveness of measuring platelet function using a near-patient platelet function analyzer for the purpose of regulating platelet transfusion and pote...